Ukulungiswa okusheshayo kwezicubu zesampula yezilwane ezisanda kuthathwa, kuvimbela umsebenzi we-RNase, kuvikela i-RNA ekonakalisweni.
-Ama-reagents asetshenziswa ngokuqondile, isinyathelo esisodwa sisendaweni, futhi i-RNA iqiniswa ngokushesha futhi ivikelwe.
-Ukusebenza ekamelweni lokushisa, kulula, kuphephile futhi akunabuthi.
-Ukuqeda inkathazo yeqhwa elomile noma isiqandisi esinezinga lokushisa eliphansi lokulondoloza izicubu.
-Izicubu zingagcinwa isikhathi eside ngaphandle kwengozi yokuwohloka kwe-RNA, kuqinisekiswe idatha ethembekile yephrofayili yokubonakaliswa kofuzo.