Ikhithi isebenzisa ikholomu ye-spin nefomula eyenziwe yi-Foregene, engakhipha kahle ubumsulwa bekhwalithi ephezulu nekhwalithi ephezulu ye-DNA ne-RNA kusuka kumasampula anjenge-plasma, i-serum, uketshezi lomzimba olungenamaseli, kanye namandla angaphezu kwamasiko. Ikhithi ingeza ngqo i-Linear Acrylamide, engabamba kalula inani elincane le-DNA ne-RNA kusuka kumasampula. Ikholomu ye-DNA / RNA-kuphela engabopha kahle i-DNA ne-RNA. Ikhithi ingacubungula inani elikhulu lamasampula ngasikhathi sinye.
Ikhithi yonke ayiqukethe i-RNase, ngakho-ke i-RNA ehlanzekile ngeke yehliswe. IBuffer RW1 neBuffer RW2 ingaqinisekisa ukuthi i-viral nucleic acid etholakala ngaphandle kwamaprotheni, i-nuclease noma okunye ukungcola, okungasetshenziswa ngqo ekuhlolweni kwe-biology yamangqamuzana esezansi.