Ikhithi isebenzisa ikholomu ye-spin nefomula eyenziwe yi-Foregene, engakhipha kahle i-RNA esezingeni eliphezulu nekhwalithi ephezulu kuzicubu zezitshalo ezahlukahlukene ezinokuqukethwe okuphezulu kwe-polysaccharides noma okuqukethwe kwe-polyphenols. Inikeza ikholomu yokuhlanza i-DNA engasusa kalula i-genomic DNA kwi-supernatant ne-lysate yezicubu. Ikholomu ye-RNA kuphela ingabopha ngempumelelo i-RNA. Ikhithi ingacubungula inani elikhulu lamasampula ngasikhathi sinye.
Ikhithi yonke ayiqukethe i-RNase, ngakho-ke i-RNA ehlanzekile ngeke yehliswe. IBuffer PRW1 neBuffer PRW2 ingaqinisekisa ukuthi i-RNA etholakele ayingcoliswanga amaprotheni, iDNA, ions, kanye nezinhlanganisela zemvelo.