Ishicilelwe ngu: West China School of Pharmacy Sichuan University

Okuqukethwe okuyinhloko: Ukwelashwa okuphumelelayo kwesifo i-Alzheimer's (AD) kuvinjwa ukungena kwesithiyo segazi nobuchopho kanye nokusatshalaliswa okungakhethi kwezidakamizwa ebuchosheni.Ngaphezu kwalokho, izindlela ze-pathological ze-AD ziyinkimbinkimbi futhi zibandakanya ukungasebenzi kwezindlela eziningi, okukhawulela ukusebenza kahle kwe-ejenti yokwelapha eyodwa.Lesi sihloko siklama i-DGL-based siRNA kanye ne-D-peptide (Dp)-elayishwe i-nanoparticles, engakhomba futhi ingene kumgoqo wegazi nobuchopho, ingene ku-parenchyma yobuchopho, futhi iqhubeke iqongelela ezilonda ze-AD, ithuthukise ukusebenza kahle kokungena kwezidakamizwa ebuchosheni, ithuthukise ukungasebenzi kahle kwengqondo nokulimala kwemizwa okubangelwa yi-AD.Funda kabanzi

Ishicilelwe ngu: West China School of Pharmacy Sichuan University

Okuqukethwe okuyinhloko: I-hypoxic microenvironment yamathumba aqinile iyimbangela ebalulekile ye-metastasis yomdlavuza.Ngakho-ke, ukuthuthukisa i-hypoxia endaweni yesimila kuyindlela ephumelelayo yokuvimbela i-tumor metastasis.Uma kuqhathaniswa nokubulala ngokuqondile amaseli wesimila, ukulungisa kabusha i-tumor microenvironment kungavimbela ukwenzeka nokuthuthukiswa kwezimila ezicini eziningi, okuyindlela yokwelapha enamandla kakhulu.Lolu cwaningo luklame inkampani yenethiwekhi enekhono lokuzihambela futhi engakwazi ukukhiqiza umoya-mpilo ngokuqhubekayo ekujuleni kwesimila.Ngesikhathi esifanayo, ngokokuqala ngqá, isu elihlangene lokuthuthukisa i-hypoxia kanye nokuvimbela i-glycolysis lahlongozwa ukuze lihlehlise ngokuphelele i-tumor microenvironment futhi kuzuzwe umphumela wokuvimbela ukuqubuka komdlavuza webele.Funda kabanzi

Ishicilelwe ngu: College of Life Sciences Sichuan University

Okuqukethwe okuyinhloko: Indlela yokubonisa i-abscisic acid (ABA) ibandakanyeka ekuphenduleni kwezitshalo esomiso kanye nengcindezi kasawoti.Nakuba indlela yokubonisa i-ABA iye yacaciswa ku-Arabidopsis, isalokhu ingatholakali ku-poplar okhuni.Kulolu cwaningo, ukuhlaziywa okubanzi kwe-genome kwezakhi zofuzo ze-poplar U-box kubonise ukuthi i-U-box E3 ubiquitin ligase gene PalPUB79 yathonywa kakhulu ngemva kwesomiso, usawoti kanye nokusayina kwe-ABA.Imiphumela yabonisa ukuthi i-PalPUB79 ilawula kahle indlela yokusayina ye-ABA, ihlinzeka ngemininingwane emisha endleleni i-PalPUB79 ethuthukisa ngayo izimpendulo zengcindezi ze-ABA ku-poplar wokhuni.Funda kabanzi

ULWAZI lomkhiqizo

Isikhathi Sangempela PCR Easyᵀᴹ-SYBR Green I Kit

IREF: QP-01012/QP-01014