Ngokwezibalo ze-Zhiliwo Big Data Platform, into emaphakathi yomthelela yokucaphuna amaphepha e-Foregene SCI ngo-February 2022 iphezulu njengo-5.8, futhi into ephezulu yomthelela ngu-8.947.
Ngokuhlaziywa kwezibalo zenani lamaphepha e-SCI emikhiqizo ye-Foregene phakathi neminyaka edlule, kutholakala ukuthi inkambiso yokukhula isobala.
I-Foregene Co., Ltd. yasungulwa ngo-2011. Kuyibhizinisi le-biotechnology elihlanganisa i-R&D, ukukhiqiza, ukuthengisa kanye nenkonzo yamakhasimende.Kusukela yasungulwa, ibigxile ekuthuthukisweni kobuchwepheshe obuhlobene ne-molecular and cell biology, imikhiqizo kanye nezinsizakalo, futhi ihlinzeka ngokuhlanzwa kwe-nucleic acid, ukutholwa kwe-nucleic acid nezinye izixazululo kubasebenzisi abaningi.Ulayini wayo womkhiqizo wocwaningo lwesayensi uhlanganisa uchungechunge lokuhlanzwa kwe-RNA, uchungechunge lokuhlanzwa kwe-DNA, uchungechunge lwe-RT/RT-PCR, uchungechunge lwe-PCR oluqondile, uchungechunge lwe-PCR Mix, uchungechunge oluqondile lwe-RT-qPCR kanye nochungechunge lwe-"Sui" lwamathuluzi ahlobene namangqamuzana.Imikhiqizo isetshenziswe kabanzi ocwaningweni oluyisisekelo emikhakheni yesayensi yezempilo, yezokwelapha, ezolimo, ezokwelapha kanye nemvelo.Amakhasimende atholakala emanyuvesi, ezikhungweni zocwaningo, ezibhedlela nakwamanye amayunithi.
U-ZhiLiaowo ukhethe imibhalo engu-6 enamaphuzu aphezulu e-Foregene ngo-February ukuze abhekise kuyo abacwaningi, ukuze abe nokuqonda okujulile nokujwayelana nemikhiqizo ye-Foregene.
Isihloko se-athikili: Ukuqina kwe-substrate kulawula ukuhlukaniswa kwamaseli e-stem e-pluripotent okuba amaseli e-valve endothelial yenhliziyo
I-DOI: 10.1016/j.actbio.2022.02.032
Isikhathi sokukhishwa: 2022-2-27
I-Foregene
Imikhiqizo Ekhonjiwe Yezincwadi
Isihloko se-athikhili: Ukuhlonza Amasiginesha e-Mitochondrial Proteome Angenzeka Ahlotshaniswa Ne-Pathogenesis ye-Pulmonary Arterial Hypertension kumodeli yegundane
I-DOI: 10.1155/2022/8401924
Isikhathi sokukhishwa: 2022-2-21
Ukusebenzisana Nombhali: Umnyango Wekhemisi, Isibhedlela Esihlanganisiwe Sokuqala sase-Xinjiang Medical University.
Abstract: I-Pulmonary arterial hypertension (PAH) yisifo esibucayi futhi esiqhubekayo esithinta inhliziyo namaphaphu futhi inkinga yezempilo yomhlaba wonke ethinta abantu nomphakathi.Kulolu cwaningo, imodeli yegundane ye-PAH eyenziwe yi-monocrotaline (MCT) yakhiwe ngempumelelo.Amaprotheni e-mitochondrial eqembu ngalinye lamagundane anqunywa ngokusebenzisa amasu we-proteomic angenayo ilebula.Ngokusekelwe ekwakhiweni nasekuthuthukisweni okusebenzayo kwamanethiwekhi we-protein-protein interaction (PPI), i-19 up-regulated mitochondrial genes kanye ne-123 ye-mitochondrial elawulwa phansi yofuzo yahlolwa kumagundane e-PAH.Ukwengeza, ekuhlolweni kwedathasethi yeqembu elizimele, imiphumela ibonise ukuthi izakhi zofuzo ze-mitochondrial ezi-6 ezilawulwa phezulu kanye nezakhi zofuzo ze-mitochondrial ezilawulwa phansi ze-3 zavezwa ngokuphawulekayo ezicutshini zamaphaphu zamagundane e-PAH.Izakhi zofuzo ezimaphakathi ze-mitochondrial eziqondiswe ku-miRNA zabikezelwa ezingeni le-transcriptome kusetshenziswa isizindalwazi se-RNAInter.Ucwaningo luphinde lwahlonza i-bortezomib ne-carfilzomib njengezidakamizwa ezingase zibe khona zokwelashwa kwe-PAH.Ekugcineni, lolu cwaningo lunikeza ukukhanya okusha kuma-biomarker abalulekile namasu okwelapha ama-PAH.
I-Foregene
Imikhiqizo Ekhonjiwe Yezincwadi
I-RT Easy II (I-Master Premix ye-First Strand cDNA Synthesis Ye-qPCR)
Inombolo yekhathalogi: RT-01021
Ukucaciswa: 50 × 10 μL rxns
Isihloko Se-athikili: Ukulahlekelwa kwe-PTEN kunikeza ukuzwela kuma-rapalogs ku-cell renal cell carcinoma ecacile
I-DOI: 10.1038/s41401-022-00862-1
Isikhathi sokukhishwa: 2022-2-14
Ukusebenzisana Nombhali: Umnyango Wekhemisi, Isibhedlela iNanfang, iSouthern Medical University, iGuangzhou, eChina
Abstract: I-Rapalog iyi-allosteric mTORC1 inhibitor kanye nomuthi ogunyaziwe we-Advanced clear cell renal cell carcinoma (ccRCC).Ucwaningo olusebenzisa imigqa yamaseli e-ccRCC amaningi atholakala esigulini lubonisa ukuthi amaseli angenayo i-PTEN abonisa ukuzwela okukhulu kuma-rapalog.Kulayini wamaseli we-ccRCC ongenawo i-PTEN, amaRapalog avimbe ukwanda kwamaseli ngokuyenga ukuboshwa kwe-G0/G1 ngaphandle kokwenza i-apoptosis.Kusetshenziswa imigqa yeseli ye-isogenic ekhiqizwa yi-CRISPR/Cas9, ucwaningo lwaqinisekisa ukuhlangana phakathi kokususwa kwe-PTEN kanye ne-Rapallo hypersensitivity.Ngokuphambene, ukususwa kwe-VHL noma izakhi zofuzo eziguqula i-chromatin (PBRM1, SETD2, BAP1, noma KDM5C) azange kuthikameze izimpendulo zeselula kuma-rapalog.Isisho se-Ectopic se-mTOR mutant esicushiwe (C1483F) siboniswe ukuthi simelane nokuvimbela ukukhula kweseli okubangelwa i-PTEN, kuyilapho ukwethulwa kwe-mTOR mutant engazweli emthini (A2034V) kuvumele amaseli e-ccRCC angenayo i-PTEN ukuthi abaleke emiphumeleni yokucindezela yokukhula yama-rapalogs.Amaseli e-ccRCC angenayo i-PTEN ayezwela kakhulu emiphumeleni evimbelayo ye-temsirolimus ekufudukeni kweseli kanye nokukhula kwesimila ku-zebrafish namagundane e-xenograft.Ucwaningo luye lwabonisa ukuthi ukususwa kwe-PTEN kuhlotshaniswa nokuzwela kwe-rapallo futhi kungasetshenziswa njengophawu lokukhethwa kwe-rapallo therapy ezigulini ze-ccRCC.
I-Foregene
Imikhiqizo Ekhonjiwe Yezincwadi
Isihloko se-athikili: Indlela enamandla ye-microbiota yamanzi angcolile anosawoti omningi anemvubelo ebekezelela usawoti kanye nokusetshenziswa kwawo
I-DOI: 10.1016/j.jece.2022.107377
Isikhathi sokukhishwa: 2022-2-12
Iyunithi yombhali: Isikole Sesayensi Yezempilo, Inyuvesi YaseJiangxi Normal
Umbono: Amanzi angcolile anosawoti omningi angamanzi angcolile ezimbonini anezingxenye eziyinkimbinkimbi, ukubola kwe-biodegradable okungekuhle kanye nokwelashwa okunzima kwe-biochemical.Ukuze kwembulwe indlela yangaphakathi yomphakathi we-microbial ekwelapheni kwamanzi angcolile anosawoti omningi ngemvubelo ebekezelela usawoti, kwenziwa ucwaningo lwezimpawu zomphakathi wamagciwane kanye nezici zemvelo.Amazinga okususwa kwesidingo somoya-mpilo wamakhemikhali, i-NH3–H kanye nenani eliphelele le-nitrogen athuthukiswe kakhulu esikalini sokuhlola se-WWTP.Imiphumela yokulandelana kwemiphumela ephezulu ibonise ukuthi i-biofortification ithinte kakhulu ukwakheka komphakathi wama-microbial.Ezingeni le-phylum, amaqembu e-Proteobacteria kanye ne-Ascomycota ahamba phambili, kuyilapho ezingeni lohlobo amaqembu e-Paracoccus ne-Meyeroi ahamba phambili.I-Meyerella idlala indima ebalulekile ekwelapheni kwamanzi angcolile anosawoti omningi, okungase kube isizathu esiyinhloko sokwenziwa ngcono kokukhipha ukungcola.Ukwengeza, i-pH, i-oksijeni encibilikisiwe, kanye nevolumu enomthelela kwakuyizici ezibalulekile ezithinta ukulandelana kwemiphakathi ye-microbial ngesikhathi se-bioaugmentation, nokho, ubuningi be-Meyerrotheca abuthintwanga ukugxilwa kokungcola okunamandla.Lolu cwaningo lwembule ngokuhlelekile izinguquko eziguquguqukayo kanye nokubikezela kokusebenza kwama-microorganisms ngesikhathi se-bioaugmentation, kanye nobudlelwano phakathi kwemiphakathi ye-microbial kanye nezici zemvelo, kwabeka isisekelo esiqinile sethiyori sokwelashwa okulandelayo kwamanzi angcolile anosawoti omningi kanye nosawoti omningi.
I-Foregene
Imikhiqizo Ekhonjiwe Yezincwadi
Isihloko Se-athikili: Ukuhlaziywa Kwe-Multi-Omics Ngemva Kokuphathwa Kwe-Vaginal ye- Bacteroides fragilis Ezinkukhu.
I-DOI: 10.3389/fmicb.2022.846011
Isikhathi sokukhishwa: 2022-2-16
Ukusebenzisana Nombhali: Ilabhorethri Ebalulekile yase-Sichuan Yokuthuthukiswa Kwezinsiza Zofuzo zezoLimo nezilwane kanye Nokusungula
Abstract: Isiqephu sokuzala sezinkukhu siyisitho esibalulekile sokwakheka kwamaqanda.Ukuxhumana okuseduze phakathi kwesitho sangasese sowesifazane nendawo yangaphandle kungase kuholele ekuhlaselweni kwamagciwane ahlukahlukene e-pathogenic, okuthinta ikhwalithi yangaphakathi nengaphandle yamaqanda, ngisho nokwandisa izinga lokufa nokudangala ukulahlekelwa kwezomnotho.Eminyakeni yamuva, ama-probiotics alethe izinzuzo zezomnotho emfuyweni nasezinkukhu ekukhiqizeni izinkukhu njengenye indlela yama-antibiotics.Imiphumela yokuphathwa kwe-vaginal ye-B. fragilis ku-chicken cloacal microbiota, i-vaginal transcriptome kanye ne-metabolome yaphenywa ukuze kuhlolwe amandla anenzuzo e-B. fragilis.Imiphumela yabonisa ukuthi ukwelashwa kwe-B. fragilis kuthinte ukwakheka kwamagciwane e-cloaca.Ukuhlaziywa kwe-Transcriptome kuthole ukuthi izakhi zofuzo ezihlobene nokuzivikela kwe-CCN3, i-HAS2, ne-RICTOR zazilawulwa phezulu, futhi izakhi zofuzo ezivuthayo i-EDNRB, TOX, ne-NKX2-3 zazilawulwa phansi, futhi ama-DEG nawo acetshiswe ekulawuleni ukuvuvukala, i-metabolism yeselula, kanye nezindlela zokuphendula ze-synaptic.Ngaphezu kwalokho, ama-metabolite ahlukene ayehlobene ngokuyinhloko ne-steroid hormone biosynthesis, i-unsaturated fatty acid biosynthesis, kanye ne-arachidonic acid metabolism, futhi ucwaningo lwahlonza izinhlangano phakathi kwama-metabolites athile ahlukile kanye nezakhi zofuzo.Sengiphetha, lolu cwaningo luhlinzeka ngesisekelo sethiyori sokusetshenziswa kwe-B. fragilis njenge-probiotic engaba khona emfuyweni nasekukhiqizweni kwezinkukhu.
I-Foregene
Imikhiqizo Ekhonjiwe Yezincwadi
I-RT Easy II (I-Master Premix yokuqala ye-cDNA synthesis ye-qPCR)
Inombolo yekhathalogi: RT-01031
Ukucaciswa: 25 × 20 μL rxns
Isihloko se-athikili: Ukuhlukahluka kofuzo kwe-Echinococcus granulosus sensu lato e-China: Izifundo ze-Epidemiological kanye nokubuyekezwa okuhlelekile
I-DOI: 10.1111/tbed.14469
Isikhathi sokukhishwa: 2022-2-9
Ukusebenzisana Nombhali: Ilabhorethri Ebalulekile yase-Sichuan Yokuthuthukiswa Kwezinsiza Zofuzo zezoLimo nezilwane kanye Nokusungula
Abstract: I-Cystic echinococcosis (CE) yisifo se-zoonotic esinganakiwe esibangelwa i-Echinococcus granulosus futhi sihlala siyinkinga enkulu yezempilo yomphakathi emhlabeni jikelele.Izinhlobo zofuzo ezikhona ezikhona ze-Echinococcus granulosus ngaphandle kwe-G4 zikhonjwe e-China, ikakhulukazi i-Qinghai-Tibet Plateau, futhi ukuhlukahluka kwazo kofuzo kuhlukile kulesi sifunda somhlaba.Ngokusho kokubuyekezwa okuhlelekile, ukwakheka kwezakhi zofuzo ze-E. granulosa ezweni lami kanje: E. granulosa (G1, G3), 98.3%;I-Echinococcus intermedius (G5), 0.1%;I-Echinococcus intermedius (G6, G7), 1.4%;kanye ne-Canada Echinococcus (G8, G10), 0.2%.Ngokukhethekile, izinga lokutheleleka kwe-G1 lalingama-97.7% futhi lalibonakala ngebanga elibanzi labasingathi kanye nokusatshalaliswa kwezindawo.Imiphumela ye-Epidemiological ibonise ukwakheka kofuzo lwe-E. coli oluzinzile futhi olucolisekile ezimvini nase-yak kusukela ezifundazweni ezintathu ze-CE ezitholakala kakhulu (i-Xinjiang, i-Sichuan, ne-Qinghai).Izimvu (287/406, 70.7%) zinenani eliphakeme lama-cysts avundile kune-yak (28/184, 15.2%).Eminyakeni engu-29 edlule, kube nama-Echinococcus granulosus cox1 haplotypes angama-51 e-China.I-haplotype yokhokho (Hap_2) yahlala iyi-haplotype evame kakhulu, ama-haplotype angu-12 avame kakhulu ayevamile, futhi ama-haplotype angu-9 asanda kubikwa atholakala phakathi nocwaningo.Okutholakele kusikisela ukuthi ukugonywa okuyisibopho kwezimvu kanye nomkhankaso wokuhlola wokugoma we-EG95 wama-yaks kuhambisana eduze nesimo samanje se-genotype.
I-Foregene
Imikhiqizo Ekhonjiwe Yezincwadi
Othintana naye:
Maggie |Ukuthuthukiswa kwama-Businesses
Inkampani Foregene Co., Ltd
M: +86-15281067355
I-URL: www.foreivd.com
Isikhathi sokuthumela: Apr-08-2022
